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This suppression of gonadotropin release can help control the timing of puberty, as a drop in melatonin levels below a specific threshold prompts the hypothalamus to trigger reproductive changes (Rijal et al., 2020

[1] Losing muscle alongside fat matters because muscle is metabolically active tissue

Structured behaviour change programmes: Services like Second Nature combine behavioural psychology with nutrition support, showing average weight losses of 6.2kg at 12 months in NHS trials

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