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Studies of serum metabolites allows for larger cohort sizes and ease of implementation but is an indirect marker of cerebral metabolism that is impacted by GI function/microbial metabolism

The SURPASS-1 trial demonstrated significant improvements in glycemic control and substantial reductions in body weight with all three doses of tirzepatide (5 mg, 10 mg, or 15 mg) compared to placebo over a 40-week period

10.1016/j.stem.2013.04.003 188 YuY

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doi: 10.1038/ncb2329 13 HerzigSShawRJ

Reviewer information Nature Reviews Disease Primers thanks H