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Such combination exhibits distinct mechanisms of action and improves the pharmacodynamic effect

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Additionally, alanine mutations of E124 3.33 and R283 6.55 also lead to the significantly diminished basal activity of the ghrelin receptor, indicating a potential role of the salt bridge formed by these residues in modulating the receptors basal activity (Supplementary Fig

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Selenium Selenium is considered as an important trace element in the modulation of oxidative stress [95].The main role of selenium is attributed to its presence in glutathione peroxidase, which protects cells from the damaging effects of free radicals