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PubMed Central Plutzky J et al

The standard cagrilintide monotherapy titration follows this schedule: 0.25 mg weekly for weeks 1-4, then 0.5 mg for weeks 5-8, then 1.0 mg for weeks 9-12, then 1.7 mg for weeks 13-16, and finally 2.4 mg for week 17 onward as the maintenance dose

To maximize its effectiveness, we recommend taking the medication on the same day each week, establishing a consistent routine that reduces the risk of missed doses

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The ideal switch would be from oral estradiol to a transdermal estradiol patch (0.05-0.1 mg/day) and from oral progesterone to either a Mirena IUD or transvaginal progesterone capsules