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It binds to melanocortin receptors (primarily MC1R) and stimulates melanogenesis the production of melanin in the skin

Similar findings were identified in comparison with metformin (HR, 0.75

The trajectories look different

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Funding This study was supported by the Italian Association for Cancer Research (AIRC IG15895 to DMN), the Italian Ministry of Health (Ricerca Finalizzata ERBA to AA) and the Azienda Agricola Fattoria La Vialla (donation to AA)