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For instance, the observed mitigation of microgliosis and pro-inflammatory cytokine release could be directly investigated by co-culturing our hCiPSC-NSCs or their conditioned medium with activated microglial cells (e.g., BV-2 cell line or primary microglia stimulated with LPS/ATP)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [163].Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J, Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Peptides may support recovery after the acute threat is addressed, but they should not delay necessary surgical intervention