Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function
10.3390/foods12203800 [DOI] [PMC free article] [PubMed] [Google Scholar] 150.Feng W, Liu J, Tan Y, Ao H, Wang J, Peng C
But if you go the doctor path, now you put everything in the hands of the prescriber, and now, ultimately, you have to hope that the prescriber knows what theyre doing
In the most directly relevant comparator with semaglutide, MASH resolution was achieved in 62.9% of patients on the drug while fibrosis improvement reached only 36.8%, leaving substantially less overlap than the headline numbers might imply [16]
This isn't a blip
The elimination half-life (t) of semaglutide was comparable between healthy subjects and subjects with type 2 Diabetes, with geometric means of 153, 161 and 158 h in healthy subjects receiving 20 mg and 40 mg doses and subjects with type 2 Diabetes receiving 40 mg, respectively
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