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A high extraction ratio inevitably leads to low oral bioavailability

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Overall, both classes are indifferently recommended by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as first-line therapy in patients with T2DM and established ASCVD or multiple ASCVD risk factors to reduce the risk of major adverse cardiovascular events (MACE), such as myocardial infarction, stroke, and cardiovascular death [6, 7]

[1] [2] These combined effects lead to improved glycemic control and significant weight loss in many patients