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Probiotics and prebiotics have demonstrated considerable potential as adjunctive strategies by reshaping the gut microbiome, modulating immune responses, optimizing metabolic function, and mitigating oxidative stress (Figure 4)

Similarly, a UK Biobank study of 240,000 workers showed that long-term NSW increased the risk of irritable bowel syndrome (IBS), with higher shift frequency and duration predicting greater incidence 154

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Indeed, chronic slight hyperinsulinemia is a pro-oxidant factor

Social isolation can also become a problem as individuals may withdraw from social settings to avoid the difficulty of hearing over their internal noise

We started treatment one day before inducing inflammation to allow carnosine to begin exerting its protective effects before the peak of inflammatory responses