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Notably, the voltage-dependent anion channel (VDAC) in the mitochondrial outer membrane, also known as the mitochondrial pore, acts as a gatekeeper for the entry and exit of mitochondrial metabolites and is a convergence point for its binding to various ligands and proteins to mediate various cell survival and cell death signals [47]
Ketogenesis occurs predominantly within the hepatic mitochondria, with carnitine palmitoyl transferase I (CPT-1) acting as the critical rate-limiting enzyme for mitochondrial fatty acid import (Figure 1)
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