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For acetaminophen overdose, NAC is administered in a hospital setting via IV

Fer-1 fails to enhance the p53/SLC7A11/GPX4 pathway but improves the Nrf2/ferroptosis inhibitory protein 1 pathway, boosting resistance to LPO (You et al., 2023)

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In this way, two toxic species, superoxide radical and hydrogen peroxide, are converted to the harmless product water

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This reaction is important because the H 2 O 2 might reduce the life expectancy of the erythrocytes for the increase in the speed of hemoglobin oxidation to metahemoglobin2 (Figure 1)