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Metabolites were normalized to total ion count of each sample

SAMe is biochemically produced through the folate-methionine cycle (see Figure 1), requiring many nutrients, including vitamin B12 and the healthy conversion of folic acid to 5-methyltetrahydrofolate (Guildford, n.d.)

In addition, Source Data are provided with this paper

The Linus Pauling Center recommends a dose of 2,000 milligrams per day, which is generally very safe and can account for the poorer absorption capacity in some individuals

Moreover, at present, there are no specific tests for diagnosing CVS

Food and Drug Administration fMRI functional MRI GLP1 glucagonlike peptide 1 NAc nucleus accumbens NTS nucleus tractus solitarius OUD opioid use disorder SPECT singlephoton emission CT SUD substance use disorder VTA ventral tegmental area 1