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This doesnt mean protein is unimportant

Increased P85 is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess

sarcopenia risk in older adults Refeeding syndrome risk in patients who are already nutritionally compromised Psychiatric Signals: What We Know and Do Not Know The largest psychiatric safety meta-analysis to date 80 randomized controlled trials, over 107,000 patients found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall, including suicidal ideation (Pierret et al., JAMA Psychiatry, 2025)

Sleep time was significantly lower in the methyl B12 group, who reported better sleep quality, focus, and a refreshed feel

Other potential confounding factors, such as differences in SOC, patient selection criteria, and GC use patterns, cannot be ruled out

July 16, 2022