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Two EMA-approved products were not assessed by any of the three HTA bodies at the time of our review (Kayfanda and Paxneury), and three products had been reviewed by all three HTA bodies (Xermelo, Luxturna, Ryeqo)

Crit Rev Clin Lab Sci 1990;28:109174

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When the subjects were asked to rate the severity on a scale from 1 to 5 (higher, more severe symptoms), they indicated bloating as the most severe symptom with a score of 4

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