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Discussion Significance of the study To our knowledge, this is the most comprehensive network meta-analysis comparing the efficacy of SL, IM, and oral routes of administration of vitamin B12 in patients with vitamin B12 deficiency

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Therefore, it may be difficult to differentiate whether the BH 4 -induced improvements in endothelial dysfunction are either due to recoupling of eNOS or due to the antioxidant properties of BH 4 itself