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In primary culture of satellite cells, the LASSS-treated HGF (Figure 1f, bars 9 and 11 , at 5 ng/ml without or with exposure to peroxynitrite, respectively) normally activates satellite cells to a level equivalent to the positive control ( bar 2 ) as revealed by BrdU-incorporation assay
However, from clinical studies alone, it is difficult to know how much of the benefit is due to direct effects in the joint and how much may be explained by weight loss or broader metabolic changes. That is why we wanted to address a basic mechanistic question first: whether GLP-1 is actually present in the joint environment
One lives in your brain, whereas the other lives in your blood vessels
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That means having to know the exact shape of the receptor
It is built on a guiding principle of using a low dose first
