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The proinflammatory microenvironment in RA synovial tissue combined with high concentrations of ROS has been shown to jointly induce neutrophils to neutrophil-dendritic (N-DC) differentiation and show more ROS generation and inflammation tendency (95)

499 Sareptas SRP-5051, an ASO conjugated with a targeting peptide, has shown higher levels of dystrophin expression and exon skipping rates than eteplirsen

The heterodimer suppressed ROS (IC 50 = 18.79 M) and IL-6 (IC 50 = 4.15 M) production more effectively than celecoxib and diclofenac

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Carotenoids are effective in scavenging peroxyl (ROO ), alkoxyl (RO ), hydroxyl ( OH), and superoxide anion radicals (O 2 )

GSH and GSSG measurement The GSH/GSSG-Glo Assay Kit (Promega, V6611) was used for luminescent-based measurement of cellular GSH and GSSG by Tecan Spark 10 microplate reader