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doi:10.1126/scitranslmed.aar7047 47

Weight reduction Obesity is a key factor in the etiology of the T2DM

Candidate neuron populations for the effects of GLP1 receptors have also been suggested within the lateral hypothalamic area and the dorsomedial hypothalamus

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89 Importantly, restoration of hypothalamic autophagy via nutritional interventions such as docosahexaenoic acid-acylated astaxanthin monoester (AST-DHA) supplementation or genetic activation of Atg5 ameliorates obesity and improves glucose metabolism in experimental models, 90 demonstrating that hypothalamic autophagy is not merely correlative but mechanistically regulatory

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