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1-sided p-value evaluated at 2.5% level for superiority 14.4 Safety Outcomes Trial DEVOTE (NCT01959529) Cardiovascular Outcomes Trial of TRESIBA Administered Once-Daily Between Dinner and Bedtime in Combination with Standard of Care in Subjects with Type 2 Diabetes and Atherosclerotic Cardiovascular Disease DEVOTE was a multi-center, multi-national, randomized, double-blinded, active-controlled, treat-to-target, event-driven trial

72 In skeletal muscle cells, GLP-1RA can activate SIRT1 through the protein kinase A and cyclic adenosine monophosphate pathways to improve IR

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Satellite cells and the repair cycle Skeletal muscle harbors a population of resident stem cells called satellite cells, which lie quiescent beneath the basal lamina until activated by loading, injury, or growth-factor signals

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