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The SURMOUNT-4 randomized clinical trial assessed the effect of tirzepatide discontinuation on the maintenance of weight reduction in adults with obesity and a weight-related complication, excluding diabetes

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Muscle regeneration timing, satellite-cell dynamics, splicing regulation, and IGFBP profiles all differ across species and across ages, [19] and effects observed in a young rodent or a cultured cell line do not transfer automatically to human physiology