10.3892/ol.2015.3995 Oncol
Superior Antioxidant Defense At the core of our skin w-h-itening cream is glutathione, a potent antioxidant that acts as a shield against free radicals
In effect, an oxidative intracellular environment may impair the function of Na + /H + antiporters, decreasing the intracellular pH and favoring an early phase of viral replication [84]
Glutathiones reduced form (GSH): Carries an extra electron (hydrogen) Donates hydrogen (electron) to inflammation-causing free radicals to neutralize their effect Glutathione peroxidase enzyme Requires selenium Converts two hydrogen peroxides into two water molecules Glutathiones oxidized form (GSSG): State of glutathione after losing its electron Forms a disulfide bridge between two glutathione molecules Glutathione reductase enzyme Glutathione can be recycled back to its reduced form using NADPH (reducing agent, electron donor)
Role of mitochondrial DNA damage in ROS-mediated pathogenesis of age-related macular degeneration (AMD)
A subsequent pilot study (n=12) comparing oral liposomal glutathione (500 mg twice daily for 2 weeks) found increases in GSH levels in whole blood, erythrocytes, and plasma, along with reductions in 8-isoprostane (a marker of oxidative stress) (Buonocore et al., Oxid Med Cell Longev, 2016) [16]
