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Clinical laboratory results indicated decreases in serum potassium after topiramate or HCTZ administration, which were greater when HCTZ and topiramate were administered in combination [see Drug Interactions (7) and Warnings and Precautions (5.12)]

However, certain clinical scenarios warrant increased vigilance

Isocitric and citric acid in human prostatic and seminal fluid: implications for prostatic metabolism and secretion

a preliminary clinical study

Prevalence of child/adolescent functional gastrointestinal disorders in a national U.S