Some of the primary differences between GLP-1 and metformin include: Mechanism GLP-1 promotes weight loss by slowing gastric emptying and reducing appetite
The choice between semaglutide and tirzepatide depends on factors like efficacy preferences, side effect profiles , insurance coverage, and provider recommendation rather than BMI differences
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Semaglutide is a single GLP-1 receptor agonist made by Novo Nordisk and sold as Ozempic, Wegovy, and Rybelsus
A 2024 study in Bone noted a 23% reduction in bone density in semaglutide users after one year, raising concerns for long-term skeletal health (link)