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Iwasaki Y, Sendo M, Dezaki K et al
The new label for Ozempic is based on the results of the FLOW trial, which showed a statistically significant reduction in kidney disease progression, as well as cardiovascular and kidney death with a 1 mg/kg weekly dose of the injectable drug compared to placebo
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People with kidney or liver disease, severe allergies, hormone-sensitive conditions like PCOS or PCOD, or genetic melanin disorders must consult their doctor first or avoid entirely
However, it is unclear if this changes are GC depended, as in patients with Cushing syndrome or under prednisolone treatment ghrelin levels are down 66,67