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When either system is disruptedby stress, travel, aging, hormone imbalances, or lifestylesleep quality suffers

The most common adverse effects are mild injection-site reactions and rare transient flushing

While Glu9 of GLP-1 formed strong and persistent hydrogen bond and van der Waals interactions with R190 2.60 , Y152 1.47 , and to a lesser extent, Y148 1.43 , the polar side chain of Gln3 in oxyntomodulin only formed weak and very transient hydrogen bonds with these residues, and van der Waals interactions only with Y148 1.43 (Movie S1, Supplementary Table 3)

thus they reduce wrinkles and improve skin tone

PMID: 113 JamilianMSamimiMMirhosseiniNEbrahimiFAAghadavodETalaeeRet al

M.BighamA.HonarmandS.TavasoliA.et al (2024)