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To reduce flexibility to favour crystallization, a disulfide bond was introduced in a flexible loop connecting the -sheet segment to the two -helices of CYTX, yielding a candidate (CYTX_B10) with improved thermal stability ( T m = 70.3 C) and monomeric profile during SEC, but a slightly weaker K d of 740 nM for N

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Ritz P, Vaurs C, Bertrand M, et al

Each peptide has its own dose-response curve, and when blended, these curves interact, making dosage determination a nuanced process

These interventions significantly improved folate and riboflavin status in vitamin-supplemented individuals compared to those taking the placebo

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