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Intrinsic sympathomimetic activity (ISA) Partial agonists Example: Pindolol Mechanism of Action 1 blockade: Heart rate Myocardial contractility Cardiac output BP 2 blockade: Bronchoconstriction Peripheral vasoconstriction Renin release from kidneys RAAS activation Clinical Indications Hypertension Ischemic heart disease / angina Post-myocardial infarction Heart failure (HFrEF carvedilol, metoprolol, bisoprolol) Arrhythmias (AF, SVT, VT) Migraine prophylaxis Hyperthyroidism / thyrotoxicosis Anxiety / stage fright (propranolol) Adverse Effects Bradycardia Hypotension Fatigue Cold extremities Worsening asthma/COPD (non-selective) Sexual dysfunction Masking of hypoglycemia symptoms (diabetics) Contraindications Severe bradycardia Heart block (2nd or 3rd degree) Decompensated heart failure Severe asthma / COPD (for non-selective) Cardiogenic shock Drug Interactions Other antihypertensives additive hypotension Antiarrhythmics bradycardia Insulin / oral hypoglycemics masked hypoglycemia 1-selective preferred in asthmatics and diabetics Abrupt withdrawal rebound angina or MI Carvedilol is used in heart failure for mortality benefit Monitor HR, BP, renal function, and blood glucose in diabetics To view or add a comment, sign in JARDIANCE (Empagliflozin) Beyond Glycemic Control Jardiance is a well-established SGLT2 inhibitor that plays a crucial role in the management of Type 2 Diabetes Mellitus, with proven cardiovascular and renal benefits

Despite the wealth of preclinical evidence showing ghrelin-induced increases in dopamine release 27,42,44 , we did not observe changes in striatal dopamine BP ND

The conditions under which PknG is stimulated to phosphorylate or dephosphorylate GarA has not yet been investigated and it is not clear how the relationship between GarA, NAD + -GDH and PknG may impact nitrogen metabolism in the mycobacteria

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Middleton J (2023): Opioid Epidemic Updates: Frankenstein Opioids and Xylazine-Induced Skin Ulcers

I am eating to ensure I get plenty of protein