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Tirzepatide is an FDA-approved drug with completed Phase 3 obesity trials, while cagrilintide is investigational, with monotherapy data only through Phase 2 and its strongest results coming from the CagriSema combination

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3.2.4 Summary Metformin is a safe and effective adjunct in HF management, particularly for patients with type 2 diabetes, and shows promise in selected non-diabetic HF populations

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