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Oral administration of Dihexa achieves 4060% bioavailability with slower absorption kinetics compared to subcutaneous injection, potentially reducing the need for daily dosing due to sustained plasma concentrations

Compared to placebo, canagliflozin was associated with an increased risk of lower limb amputations (6.3 versus 3.4 participants with amputations per 1,000 person-years

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The midline fluid percussion injury model entails delivery of a brief pulse of fluid to the intact dura