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Gut-related peptides Metformin and glucagon-like peptide 1 Metformin treatment has been shown to increase the glucagon-like peptide 1 (GLP-1) concentration in both mouse and human studies [5063]

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This may be because they calm overactive immune responses, including in people with Mast Cell Activation Syndrome (MCAS)a condition where the bodys allergy cells overreact

Yang L, Gaikwad NW, Meza J, Cavalieri EL, Muti P, Trock B, Rogan EG