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The orexigenic effect is mediated through GHSR-1a activation of NPY/AgRP neurons in the hypothalamus, with downstream engagement of reward circuits in the ventral tegmental area (Ghrelin signaling in VTA, 2015)

Some patients report improved focus while using Mounjaro, especially as blood sugar levels become more stable

Handling: Let frozen vials warm to room temperature before opening, and keep the solution clear of heat and direct light

However, the plausible actions of GLP-1RAs on several reward domains may require more nuanced interpretation

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Patient's started on a lower dose and then built up gradually to reduce side effects