doi: 10.1111/cen.12524 178 ManciniALeoneESilvestriniAFestaRDi DonnaVDe MarinisLet al
Not for pregnant or lactating women.
While preclinical studies have provided important mechanistic insights into the CV effects of GLP-1RAs, many experimental models of atherosclerosis, MI, or heart failure were conducted in mice that, despite being fed an HFD or HCD, do not develop the severe obesity or T2D that characterize patients treated with GLP-1RAs in CVOTs
[DOI] [PubMed] [Google Scholar] 112.Greetham D., Morgan C., Campbell A.M., van Rossum A.J., Barrett J., Brophy P.M
Fritz IB
Their half-lives in the body are relatively short, so they dont stick around long enough to have a lasting effect