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Through the activation of Nrf2, SFN inhibited hepatic glucose production and decreased the expression of key enzymes in gluconeogenesis in HFD-induced diabetic rats, and reversed the gene expression profiles of the hepatic disease signature of diabetes

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Multiple studies link the mTOR pathway to aging

In animal studies, systemic TB-500 administration improved cardiac muscle survival post-infarction, enhanced dermal and corneal repair, and reduced inflammatory cytokines in sepsis and neural injury models

MedChemComm 8(8):15921603 Fotsis T et al (1993) Genistein, a dietary-derived inhibitor of in vitro angiogenesis