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Citation132 JAK/STAT Pathway: The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is involved in the inflammatory signaling of senescent cells

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Important safety considerations include the risk of acute pancreatitis (seek urgent medical attention for severe, persistent abdominal pain), gallbladder disease, and potential worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy who experience rapid improvement in blood glucose control

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