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Diabetes Ther 15 , 547563 (2024)

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Due to the role played by GSH in regulating redox balance, some molecules involved in GSH metabolism, such as glutathione peroxidase 4 (GPX4), GCLC and the cystine transporter solute carrier family 7 member 11 (SLC7A11), have been reported to inhibit the ferroptosis of cancer cells 38,39,40,41,42,43,44

These findings indicate that B12 may play a role in reducing inflammation and supporting metabolic health

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Moreover, ErbB2 can form heterodimers with IGF-IR in IGF-IR inhibitor-resistant cancer cells, leading to the induction of ErbB2 phosphorylation by IGF2 [177]