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However, owing to its bicyclic backbone structure limitations, an LNA can only spontaneously form A-type hybrid duplexes with target nucleic acid strands

For this reason, sulfate assimilation, which is highly regulated by the demand for reduced sulfur, is also notably dependent on the nitrogen status ( 2 S), cysteine, S-adenosyl-methionine (SAM) and glutathione, exert inhibitory effects at the post-translational level (Wirtz et al., 2010)

Overstimulation of metalloproteinases (MMPs), enzymes that break down collagen and elastin

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