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Only the branded versions Wegovy, Ozempic, Zepbound, Mounjaro, Saxenda, Rybelsus, Trulicity, and Victoza are FDA-approved

In the kidney, GLP-1 receptors are predominantly expressed on vascular smooth muscle cells of the afferent arteriole [63]

We have also summarized the drugs that are clinically used for UC treatment, including mainly aminosalicylic acid preparations, corticosteroids and biologics

Semaglutide and tirzepatide are GLP-1 receptor agonists (tirzepatide also targets GIP receptors) approved for weight management and type 2 diabetes

Elevated intracellular iron levels facilitate the generation of ROS through Fenton chemistry, subsequently initiating lipid peroxidation reactions (20)

Per the prescribing information, it is also recommended that a reduction in the dose of pre-existing insulin secretagogue medications be considered when initiating liraglutide to minimize the risk of treatment-emergent hypoglycemia