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ZXGD inhibited HIF-1-mediated pulmonary vascular remodeling To identify the key modulator in therapeutic targets network of ZXGD against pulmonary vascular remodeling, we first examined expression of HIF-1 gene in lung tissues, then silenced HIF-1 gene using siRNA transfection and evaluated the critical markers of proliferation, apoptosis, hypoxia, inflammation, cholesterol, lipid droplets, and lipid toxicity among therapeutic targets of ZXGD in vitro using MTT, PCR, ELISA, and Western blot assays

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