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It acts directly on several target tissues, including skeletal muscle and bone, but several effects are mediated indirectly by circulating (liver-derived) or locally produced IGF-1

So there are a lot of redundancies in these pathways, but it's really quite amazing when you see how the body is organized

Its interaction with oxidative pathways has made it a valuable research tool for studying cellular resilience, environmental stress responses, and metabolic adaptation

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