GLP-1 microdosing refers to using semaglutide (Ozempic/Wegovy) or tirzepatide (Mounjaro/Zepbound) at doses intentionally below the standard therapeutic range capturing the drugs metabolic benefits with a more gradual, tolerable titration profile
Why it matters: GLP-1 use surged in 2025 and will grow this year as the drugs expand beyond diabetes and weight loss into cardiovascular, kidney and liver disease, sleep apnea, and other indications in development
Much like any surgery has its risks, these medications also have theirs, notes Dr
At a cellular level, owing to its oxidation of cellular glutathione (GSH) and its reduction of cellular hydrogen peroxide, GPx1 influences the thiol redox state and maintains the balance between necessary and harmful levels of cellular oxidants
Multiple studies have demonstrated that testosterone induces OS in the muscle, testis, and human placenta (76)
Cuperlovic-Culf M role of glutathione in cancer: from mechanisms to therapies
