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Histopathological examinations often reveal canalicular bile plugs and periportal inflammation, supporting a direct toxic mechanism

Chem Biol 15:234245 Wewer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L et al (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS

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If gastrointestinal symptoms significantly impair quality of life or prevent medication adherence despite conservative management, healthcare providers may consider dose adjustment, alternative agents with potentially different side effect profiles, or referral to a gastroenterologist for specialized evaluation

Key reconstitution rules: Use bacteriostatic water (not sterile water) for multi-use vials Add water slowly along the vial wall, never directly onto the powder Swirl gently to dissolve