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Hydroxysteroid (17-) dehydrogenase 13 (HSD17B13) is a gene encoding the hepatic lipid droplet protein 17-hydroxysteroid dehydrogenase type 13 and it has been found that HSD17B13 expression is markedly upregulated in patients and mice with MASLD, suggesting that HSD17B13 usually produces a product that promotes hepatocyte injury (100)

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The copper ion in GHK-Cu participates in superoxide dismutase (SOD) activation and enzyme cofactor activity, making the complex more biologically active than uncomplexed GHK in most published models

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In contrast, enhanced coatomer-binding due to clientization likely prevents S release, thereby affecting S incorporation into virions