alternatives to tirzepatide vs. Retatrutide: Key Differences Explained Important Update: Compounded Tirzepatide Phasing

Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs

4 Commonly used for type 2 diabetes and weight management, it acts on receptors in the brain, gut, and fat tissue, influencing appetite, blood sugar, and how the body handles fat

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It does this by cutting down appetite and making digestion slower

In fact, appetite suppression, which drives the caloric deficit that causes fatigue, is one of the primary mechanisms through which the medication produces weight loss

However, they each target these incretins differently