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As Poulopoulos observed, Behavior, not just biology, will determine long-term mortality outcomes. Even if GLP-1 therapies ultimately improve population health, their impact on insured portfolios may be more modest than headline projections suggest

Copper is essential for enzymes like lysyl oxidase (which cross-links collagen and elastin) and superoxide dismutase (an antioxidant)

The discoid morphology and other responses such as contraction of cristae, increasing or decreasing the synthesis of ETC complexes, and changing expression of uncoupling proteins can affect the efficiency of oxidative phosphorylation