Extrahepatic manifestations of paediatric PFIC Extrahepatic symptoms are often observed in paediatric patients with PFIC subtypes if the affected gene is highly expressed in tissues other than the liver [55] (Fig
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For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]