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Regarding the material for cholesterol synthesis, the levels of Acetyl-CoA are decreased whether metformin is used alone, simvastatin is used alone, or both are used in combination (Fig

Proc Natl Acad Sci USA 93:1442814433 Winterbourn CC, Metodiewa D (1994) The reaction of superoxide with reduced glutathione

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Among these are neurodegenerative diseases, which are characterized by progressive neuronal impairment or loss leading to cognitive and motor decline ( Although direct evidence of CHAC1 involvement in human neurodegeneration remains limited, its well-established role in GSH catabolism positions it mechanistically at the intersection of ferroptotic pathways

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