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(2013) showed that Sod1 -/- mice have impaired sperm motility and in vivo fertilization compared to WT animals

Therefore, targeting the HIF signaling pathway and its regulated downstream gene expression has become a potential strategy for treating hypoxia-related diseases

Nutrients 13:1602

This process not only regulates the abnormal behavior of inflammatory synovial cells and corrects the dysregulation of immune cell function, but also improves the imbalance of bone metabolism (see Figure 3)