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Neuron 39(6):889909 Lees AJ, Hardy J, Revesz T (2009) Parkinsons disease Lancet Lond Engl 373:20552066 Graham JM, Paley MN, Grnewald RA, Hoggard N, Griffiths PD (2000) Brain iron deposition in Parkinsons disease imaged using the PRIME magnetic resonance sequence
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The peptide reduces production of pro-inflammatory cytokines including IL-1, TNF-, and IL-6 while enhancing expression of anti-inflammatory mediators such as IL-10 and TGF-, creating a cytokine milieu that supports tissue repair rather than ongoing damage
Safety Profile and Possible Side Effects Preclinical studies show BPC-157 was well-tolerated with no serious toxicity in mice, rats, rabbits, and dogs