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Over 12 months, lixisenatide produced a modest 3-point improvement on a 132-point motor disability scale compared with placebo, primarily due to deterioration in the placebo group

It works by activating melanocortin receptors throughout the body, including pathways involved in melanin production, desire and arousal signaling, appetite and satiety, inflammatory balance, and broader mind-body communication

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The aforementioned studies also demonstrated that Treg cells could not only mitigate neurological damage, but also regulate the steady-state of peripheral immune responses, including the correction of immune suppression and the reduction of peripheral inflammation (82)