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Moreover, ferroptotic activation induces overexpression of matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), which disrupts articular cartilage metabolic homeostasis and potentiates ECM degradation, thereby driving OA progression (Sheng et al., 2025)

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[70] reported that in post-stroke patients, the risk of cognitive impairment was inversely correlated with plasma choline levels

If you suspect B12 is affecting your skin, keeping a symptom diary noting when you take supplements and when breakouts occur can help your GP assess the relationship